Can sildenafil cause neuropathy?

Asked by: Dr. Faustino Schuster  |  Last update: May 13, 2023
Score: 4.5/5 (48 votes)

Conclusion. These results suggest that sildenafil is active in causing neuropathic pain. Both GABAA and GABAB receptors are involved in the antinociceptive effect of sildenafil.

Does sildenafil help neuropathy?

Sildenafil improves neuropathy in long-term diabetic mice

As the homozygotes age, they develop slowed sensory and motor nerve conduction velocity (SCV and MCV), increased motor latency, and decreased intraepidermal nerve fiber density as compared to non-diabetic control mice.

Can you take Viagra with neuropathy?

Experimental data show that treatment of diabetic peripheral neuropathy with a potent PDE5 inhibitor, sildenafil, improves blood supply to the sciatic nerve [6,7]. Patients with diabetic peripheral neuropathy who are treated for erectile dysfunction with sildenafil have reduced symptoms of neuropathy [8].

What medications can lead to neuropathy?

Other drugs and substances that may cause neuropathy include: Colchicine (used to treat gout) Disulfiram (used to treat alcohol use) Arsenic.
...
Drugs used to fight infections:
  • Chloroquine.
  • Dapsone.
  • Isoniazid (INH), used against tuberculosis.
  • Metronidazole (Flagyl)
  • Nitrofurantoin.
  • Thalidomide (used to fight leprosy)

Can Viagra cause numbness?

tingling in the arms, feet, legs, or hands. numbness in the arms, feet, legs, or hands. headache.

Can homeopathy reverse Peripheral Neuropathy? - Dr. Sanjay Panicker

21 related questions found

What are the long term side effects of sildenafil?

Cerebrovascular and Cardiovascular

Vascular side effects are seen in long-term users of Viagra, such as cerebrovascular haemorrhage and Transient Ischemic Attack (TIA). Cardiomyopathy (enlarged heart), arrhythmia (irregular heartbeat), and heart palpitations have been reported.

Can sildenafil cause joint pain?

CONCLUSION. Sildenafil use may cause gouty arthritis, and surgical decompression may be helpful for definitive diagnosis and symptom relief in atypical presentation of gout.

How long does it take for drug induced neuropathy to go away?

Those who experienced neuropathy reported paresthesia, confirmed by nerve conduction studies, about 3 months after starting the drug, and stopping the drug reversed the symptoms [44].

What are the warning signs of neuropathy?

The Top 17 Peripheral Neuropathy Warning Signs and Symptoms
  • burning pain radiating in hands or feet.
  • pins and needles in the extremities.
  • numbness and tingling.
  • weakness in arms and legs.
  • a knotted feeling in the soles and palms.
  • pain from the lightest touches.
  • difficulty walking.
  • pain from the pressure of walking.

How do you calm down neuropathy?

Regular exercise, such as walking three times a week, can reduce neuropathy pain, improve muscle strength and help control blood sugar levels. Gentle routines such as yoga and tai chi might also help. Quit smoking.

Can Viagra cause nerve pain?

Conclusion. These results suggest that sildenafil is active in causing neuropathic pain. Both GABAA and GABAB receptors are involved in the antinociceptive effect of sildenafil.

Can ED caused by nerve damage be reversed?

In many cases, yes, erectile dysfunction can be reversed. A study published in the Journal of Sexual Medicine found a remission rate of 29 percent after 5 years. It is important to note that even when ED cannot be cured, the right treatment can reduce or eliminate symptoms.

Can Viagra cause leg pain?

Some Viagra users experience muscle aches after taking the medication. This can range from a mild level of muscular pain to pain in a specific area, such as the lower back. Muscle aches and pain after using Viagra can be treated using over-the-counter pain relief medications.

Does peripheral neuropathy affect erections?

A man may experience something that makes him excited, but the erection just doesn't happen. What is neuropathy? The medical term for this nerve damage is neuropathy. The type of neuropathy associated with erectile dysfunction (ED) is called peripheral neuropathy.

How does neuropathy affect ED?

Researchers have uncovered clear links between erectile dysfunction (ED) and peripheral neuropathy. This study of 90 patients shows that men with more severe symptoms of peripheral neuropathy, which can be caused by disease, trauma or illness, had greater self-reported ED and required more aggressive treatment.

What nerve damage causes ED?

The cavernous nerves that innervate the penis arise from the portion of the pelvic plexus. The pelvic plexus also contains nerves that innervate the rectum, bladder and urinary sphincter and the nerve projections can be damaged during radical excision of the bladder, prostate and rectum, leading to iatrogenic ED (4).

How do you stop neuropathy from progressing?

How To Slow The Progression of Diabetic Neuropathies
  1. Losing weight.
  2. Exercising.
  3. Control blood sugar levels.
  4. Quit smoking.
  5. Stop drinking alcohol.
  6. Treat all injuries and infections right away.
  7. Improving vitamin deficiencies.
  8. Managing stress.

Where does neuropathy usually start?

Neuropathies frequently start in your hands and feet, but other parts of your body can be affected too. Neuropathy, often called peripheral neuropathy, indicates a problem within the peripheral nervous system. Your peripheral nervous system is the network of nerves outside your brain and spinal cord.

What are the beginning stages of neuropathy?

Signs and symptoms of peripheral neuropathy might include:
  • Gradual onset of numbness, prickling or tingling in your feet or hands, which can spread upward into your legs and arms.
  • Sharp, jabbing, throbbing or burning pain.
  • Extreme sensitivity to touch.

How can I reverse neuropathy naturally?

8 natural treatments for peripheral neuropathy
  1. Vitamins. Some cases of peripheral neuropathy are related to vitamin deficiencies. ...
  2. Cayenne pepper. Cayenne pepper contains capsaicin, an ingredient in hot peppers that makes them spicy. ...
  3. Quit smoking. ...
  4. Warm bath. ...
  5. Exercise. ...
  6. Essential oils. ...
  7. Meditation. ...
  8. Acupuncture.

What causes neuropathy to flare up?

It's usually caused by chronic, progressive nerve disease, and it can also occur as the result of injury or infection. If you have chronic neuropathic pain, it can flare up at any time without an obvious pain-inducing event or factor. Acute neuropathic pain, while uncommon, can occur as well.

What's the latest treatment for neuropathy?

Gabapentin and Pregabalin have been approved by the Food and Drug Administration (FDA) for the treatment of neuropathic pain.

Does sildenafil cause inflammation?

[32] confirmed a strong anti-inflammatory effect of sildenafil as a result of influence on TNF-α, IFN-γ, IL-2, and IL-1β production in cerebella in sildenafil-treated MS mice. Nunes et al.

What medications should not be taken with sildenafil?

Before taking sildenafil,

do not take sildenafil if you are taking or have recently taken riociguat (Adempas) or nitrates (medications for chest pain) such as isosorbide dinitrate (Isordil), isosorbide mononitrate (Monoket), and nitroglycerin (Minitran, Nitro-Dur, Nitromist, Nitrostat, others).

How can I reduce the side effects of sildenafil?

Most of the mild side effects of Viagra either tend to go away within a few hours of taking your dose or can be easily relieved. For example, headaches, flushing, and dizziness can often be eased by lying down and resting. Avoiding alcohol will also help reduce these side effects.