How much Shingrix is injected?

Asked by: Tristin Carter  |  Last update: September 18, 2025
Score: 4.8/5 (44 votes)

SHINGRIX is a suspension for injection supplied as a single-dose vial of lyophilized gE antigen component to be reconstituted with the accompanying vial of AS01B adjuvant suspension component. A single dose after reconstitution is 0.5 mL.

How many doses of Shingrix are needed to complete the series?

CDC recommends 2 doses of Shingrix separated by 2–6 months for immunocompetent adults aged 50 years and older: Whether or not they report a prior episode of herpes zoster. Whether or not they report a prior dose of Zostavax, a shingles vaccine that is no longer available for use in the United States.

Is Shingrix 2 doses?

SHINGRIX is a 2-dose series, with the second dose administered 2 to 6 months after the first. Completing both doses is the only way to get the full protection offered by SHINGRIX, so stay on schedule for your second dose with text, email, and voice reminders.

What is the volume of Shingrix injections?

Shingrix Dosage and Administration

Give by IM inj in deltoid region of upper arm. ≥50yrs: one 0.5mL dose at Month 0 followed by second dose given between 2–6 months later. Immunocompromised (≥18yrs): one 0.5mL dose at Month 0 followed by second dose given between 1–2 months later.

How effective is Shingrix after one shot?

ONE DOSE VACCINE EFFICACY

One-dose VE in the ≥ 50 years of age (ZOE-50 study) and ≥ 70 years of age (ZOE-50-ZOE-70 pooled analysis) cohorts are presented in Table 1. VE (95% CI) of 1 dose of Shingrix in adults ≥ 50 years of age and ≥ 70 years of age was 90.8% (62.1-99.0%) and 69.5% (24.9-89.1%) respectively.

What You Should Know About Shingles Vaccines | Johns Hopkins Medicine

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Are the side effects of the second Shingrix shot worse than the first?

In many cases, you may experience similar side effects from both your first and second shot. However, in clinical trials , after receiving the second dose of Shingrix, headache and shivering were reported more often. So after your second dose of Shingrix, you may be at a higher risk of these side effects occurring.

Is one shot enough to prevent shingles?

The CDC recommends two doses of the shingles vaccine for adults fifty years or older. Hepatitis B is administered across a three-dose series, starting as early as infancy, and HPV is recommended as a two-dose series available from ages nine through twenty-six.

Is there a downside to the shingles vaccine?

The most common side effects of a shingles vaccine are headaches and pain, soreness, swelling and itching where the shot was given. On white skin, the area might look red. On Black or brown skin the redness might be harder to see.

When is it too late to get the second shingles vaccine?

These results reinforced the importance of getting the second dose. But even if you miss the usual two-to-six-month window for the booster, it may not be too late. The researchers also found that the vaccine's effectiveness did not suffer if the second dose was delayed beyond six months.

Does one Shingrix shot provide protection?

Shingrix is given in 2 doses given about 6 months apart. The study found 2 doses were 76% effective against shingles, while 1 dose was 64% effective. Over the 4-year period, the 2-dose regimen waned little while the single dose waned more, dropping to 52% after the third year.

What percentage of people have a bad reaction to Shingrix?

Adverse events of arthralgia, infective pneumonia, and influenza-like illnesses occurred in ≥1% of recipients of SHINGRIX and at a rate at least 1.5-fold higher than placebo (1.5% vs 1.0%, 1.5% vs 0.9%, and 1.3% vs 0.6%, respectively).

Does the shingles vaccine last a lifetime?

Immunity from the vaccine lessens over time, but it does so very gradually. Studies have shown that among people age 70 and older, Shingrix provides at least 85% protection against shingles for up to four years after completing the two-dose series,3 and remains high for at least seven years.

What medications should I avoid after the shingles vaccine?

There may be an interaction between herpes zoster vaccine and any of the following:
  • acetaminophen.
  • anakinra.
  • azathioprine.
  • baricitinib.
  • cancer medications (e.g., carboplatin, cyclophosphamide, doxorubicin, ifosfamide, venetoclax, vincristine)

Is there a difference between the first and second shingles shot?

It's important to get both shots of Shingrix to ensure the best protection against shingles and its complications. Shingrix is safe and effective for most people. Side effects from the second dose of Shingrix are somewhat more common than the first dose, although that's not always the case.

Why do some doctors not recommend the shingles vaccine?

But safety in pregnant women has not been proven yet, and so it is not recommended during pregnancy. Severe reaction to an earlier dose. If you had a severe allergic reaction after the first dose of RZV, you shouldn't have the second dose. Be careful also if you have had allergic reactions to other vaccines.

Why was Shingrix recalled?

The recall is a precautionary measure due to the potential for loss of integrity of the antigen vial, although a search of GSK's global adverse event database has not identified a safety signal for Shingrix lot #9LH3Y related to infections or lack of efficacy, events that could occur if there were a loss of integrity ...

How often do you need a shingles shot after 65?

The Centers for Disease Control and Prevention (CDC) recommends that healthy adults age 50 years and older get two doses of Shingrix separated by two to six months. Vaccination is also recommended for some adults age 19 and older who have compromised immune systems.

What happens if you get a third Shingrix shot?

The Shingrix vaccine is approved by the Food and Drug Administration for use in preventing shingles, but the administration of a third dose is investigational. Adding a third dose of the Shingrix vaccine may improve immune response and protection in patients who have undergone an allogeneic stem cell transplant.

How common is Guillain-Barré after Shingrix?

In a post-marketing observational study in individuals aged 65 years or older, an increased risk of Guillain-Barré syndrome (estimated 3 excess cases per million doses administered) was observed during the 42 days following vaccination with Shingrix.

What happens if you don't get the second shingles shot?

If you received one dose of the Shingrix® vaccine but a shortage kept you from getting your second dose – a painful case of shingles still could be in your future. The makers of Shingrix claim its protection is sustained at a high level for at least four years – but only if you get both doses two to six months apart.

What triggers shingles to flare up?

After having chickenpox, the virus stays in the nerve cells of your body but is not active. Shingles occurs when the virus becomes active again usually many years later. The virus may be reactivated by stress, illness, immunosuppression, older age, trauma and radiotherapy. But shingles often occurs for no known reason.

Why was the shingles vaccine taken off the market?

Merck & Co.'s Zostavax was discontinued in 2020 because of waning effectiveness over time. Curevo hopes to change that and go head-to-head with GSK's Shingrix — which notched $4.3 billion sales last year — with a vaccine that's as effective but has a lower rate of side effects.

What are the first signs of shingles?

Early symptoms

People can have pain, itching, or tingling in the area where the rash will develop. This early warning sign can happen several days before the rash appears. People can also have a fever before the rash appears.

What age is the shingles vaccine free?

You'll remain eligible until your 80th birthday (but you can have your 2nd dose up until your 81st birthday). Information: If you turned 65 before 1 September 2023, you'll be eligible for the shingles vaccine when you turn 70. Everyone aged 70 to 79 is eligible for the shingles vaccine.