Is Eliquis toxic to the liver?

Asked by: Ernestina Gusikowski MD  |  Last update: September 14, 2025
Score: 4.3/5 (5 votes)

Liver toxicity tended to occur within days of starting Eliquis and resolved rapidly once Eliquis was discontinued. The rate of liver injury with Eliquis appears similar to that of rivaroxaban. Signs of liver injury/toxicity include: Yellowish tone to the skin and eyes.

What organs does Eliquis affect?

However, Eliquis can sometimes cause serious bleeding. This may include bleeding in organs such as the kidneys. In clinical trials, some people taking Eliquis reported having blood in their urine, which could be a sign of bleeding in the kidneys.

What is the safest blood thinner for the liver?

The use of apixaban for stroke prevention in patients with atrial fibrillation (AF) and liver cirrhosis appears to be safer than other common anticoagulants, a new observational study shows.

How long can you safely take Eliquis?

For preventing blood clots and stroke in AFib, Eliquis is meant to be used as a long-term treatment. So if you and your doctor determine that Eliquis is safe and effective for you, you'll likely take it long term. However, to treat or prevent DVT or PE, you'll typically take Eliquis for a few months.

What are the 10 worst medications for your liver?

Prescription drugs:
  • Statins.
  • Antibiotics like amoxicillin-clavulanate or erythromycin.
  • Arthritis drugs like azathioprine or methotrexate.
  • Antifungal drugs.
  • Niacin.
  • Steroids.
  • Allopurinol for gout.
  • Antiviral drugs for HIV infection.

Side-effects to taking blood thinners

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What is the best drink to flush your liver?

Tumeric tea is considered one of the best drinks for liver detox. Studies show that turmeric has properties that can decrease the key pro-inflammatory molecules that initiate, develop, or worsen diseases like liver disease.

What is the best vitamin for liver repair?

Best vitamins for liver health: What does science say about taking vitamins for liver repair?
  • Vitamin E. Vitamin E is a fat-soluble compound that helps protect cell membranes from oxidation and destruction. ...
  • Vitamin D. Chronic liver diseases are often associated with vitamin D deficiency. ...
  • Vitamin C. ...
  • Vitamin B.

What is the downside of taking Eliquis?

ELIQUIS can cause bleeding, which can be serious, and rarely may lead to death. This is because ELIQUIS is a blood thinner medicine that reduces blood clotting.

Why did they take Eliquis off the market?

Eliquis lawsuits claim clinical trials supporting the blood thinner's approval was flawed, leading to patient injuries. The FDA delayed approval for nine months due to misconduct and errors in a trial site in China.

What should you not drink with Eliquis?

It's possible that grapefruit and grapefruit juice may interact with Eliquis. Taking the medication with grapefruit products may raise the level of Eliquis in your body. This may increase your risk of bleeding.

Does Eliquis hurt your liver?

Increased liver enzymes and liver injury

Liver toxicity tended to occur within days of starting Eliquis and resolved rapidly once Eliquis was discontinued. The rate of liver injury with Eliquis appears similar to that of rivaroxaban. Signs of liver injury/toxicity include: Yellowish tone to the skin and eyes.

What can I take instead of Eliquis?

Eliquis alternatives encompass a range of anticoagulant medications like Xarelto, Pradaxa, and Savaysa. These options offer convenient dosing, reduced bleeding risks, and improved patient adherence compared to traditional anticoagulants.

Can you live with AFib without blood thinners?

“There are clinical trials that we were part of that are essentially giving patients the option of having a WATCHMAN device as a first-line therapy,” Morgan said, which would mean that A-fib patients would never have to go on blood thinners for their condition.” “It's very safe.

Is 5 mg of Eliquis twice a day a lot?

The usual dose in adults if you: have a heart condition called atrial fibrillation is one 5mg tablet, taken twice a day. Your doctor may prescribe a lower dose of one 2.5mg tablet twice a day if you're over 80 years old, weigh less than 60kg (9st 6lb), or have kidney disease and are at higher risk of bleeding.

What fruits should be avoided when taking Eliquis?

Foods that may increase the concentration of Eliquis® in your system
  • Grapefruit juice.
  • Lime juice.
  • Oats.
  • Mangoes.
  • Wild blueberries.
  • Fish oil.

Can you eat eggs on blood thinners?

On the positive side, patients are able to consume many foods considered safe if they are taking any anticoagulants. These are the foods that are considered safe to consume: Meat, fish, and eggs.

Why are doctors pushing Eliquis?

In this study, ELIQUIS significantly reduced the risk of having another DVT/PE after initial treatment versus placebo. Based on these results, ELIQUIS was approved to reduce the risk of DVT/PE blood clots occurring again. ELIQUIS can cause bleeding, which can be serious, and rarely may lead to death.

Is Eliquis going generic in 2024?

Eliquis was approved by the U.S. Food and Drug Administration (FDA) in 2012 as a brand-name drug. Although a generic was approved in 2019, generic apixaban will not be available on the market until at least April 2028.

Why is Eliquis being recalled?

Bristol-Myers Squibb is taking this precautionary measure based on a customer complaint that a bottle labeled as Eliquis 5 mg was found to contain Eliquis 2.5 mg tablets. Patients should not stop taking Eliquis without consulting with their physician.

Why can't you eat salad on blood thinners?

However, for some individuals on the medication Coumadin, eating salads can be worrisome because many lettuces and trendy greens are rich in vitamin K, which can interfere with this medication. Coumadin is prescribed to reduce the risk of forming blood clots.

What supplements should not be taken with Eliquis?

Eliquis and Pradaxa are both taken twice a day. It is very important not to miss a dose! (This means making sure you do not run out of samples or refills as well.) While taking any of the medications listed above a patient should stop the following supplements: fish oil, krill oil, vitamin E, garlic, and bromelaine.

Why do doctors prefer Eliquis?

Eliquis reduces the risk of forming a blood clot in the legs and lungs of people who have just had hip or knee replacement surgery. Eliquis treats blood clots in the veins of your legs (DVT - deep vein thrombosis) or lungs (pulmonary embolism), and reduce the risk of them occurring again.

What is the super food for the liver?

Top foods and drinks for liver health
  • Coffee. A 2021 study analyzed data from 494,585 people in the United Kingdom to learn how different types of coffee might affect the risk of chronic liver disease, including decaffeinated, instant, and ground coffee. ...
  • Oatmeal. ...
  • Green tea. ...
  • Garlic. ...
  • Berries. ...
  • Grapes. ...
  • Grapefruit. ...
  • Prickly pear.

What heals the liver the fastest?

Foods that support liver health tend to be high in fiber, antioxidants, or healthy fats. These include things like berries, cruciferous vegetables, beans, nuts, and fatty fish. Avoiding certain foods — like processed foods and alcohol — will also help with liver repair.

Is banana good for the liver?

​​Bananas​

Vitamins B6, C, and A are abundant in bananas. Additionally, it has a lot of resistant starch, which is excellent for the health of the liver. These nutrients guarantee that the liver operates properly.