Is tacrolimus the same as Prograf?

Asked by: Prof. Harry Reilly Jr.  |  Last update: August 8, 2022
Score: 4.5/5 (44 votes)

Tacrolimus (Prograf ®) is an immunosuppressant drug used to prevent and treat organ rejection

organ rejection
Transplant rejection occurs when transplanted tissue is rejected by the recipient's immune system, which destroys the transplanted tissue. Transplant rejection can be lessened by determining the molecular similitude between donor and recipient and by use of immunosuppressant drugs after transplant. › wiki › Transplant_rejection
in children who have had liver transplants. It is used for long-term immunosuppression.

Is tacrolimus generic for Prograf?

Tacrolimus comes as the brand-name drugs Astagraf XL, Envarsus XR, Prograf, and Protopic. Like the different forms of generic tacrolimus, these brand-name drugs do not all have the same uses.

What is another name for Prograf?

Tacrolimus (Astagraf XL, Envarsus XR, Prograf) is used along with other medications to prevent rejection (attack of a transplanted organ by the immune system of a person receiving the organ) in people who have received a kidney transplant.

What is tacrolimus other name?

US Brand Name
  • Astagraf XL.
  • Envarsus XR.
  • Hecoria.
  • Prograf.

What is the generic for Prograf?


Transplant Pharmacy - Your guide to taking tacrolimus (both Advagraf and Prograf)

44 related questions found

Is tacrolimus a high risk drug?

Tacrolimus is a very strong medicine. It can cause side effects that can be very serious, such as kidney problems. It may also decrease the body's ability to fight infections. You and your doctor should talk about the benefits of this medicine as well as the risks of using it.

Why is tacrolimus in short supply?

A: We do not know all of the reasons why tacrolimus is in shortage. One reason is a raw ingredient shortage leading to manufacturer delays in producing tacrolimus. Generic tacrolimus is being allotted to pharmacies based on past usage.

How long do you take tacrolimus after kidney transplant?

Three-year posttransplant graft survival in renal-transplant patients with graft function at 6 months receiving tacrolimus or cyclosporine microemulsion within a triple-drug regimen. Transplantation 2003; 76:1686. Williams D, Haragsim L. Calcineurin nephrotoxicity.

How long can you take tacrolimus?

How long will I have to take tacrolimus? You will likely be on this immunosuppressant or one similar to it for as long as your transplanted organ is functioning. Over time, there may be some changes to the types of immunosuppressants you will take.

Who should not take tacrolimus?

You should not use this medicine if you are allergic to tacrolimus or hydrogenated castor oil, or if you have used cyclosporine (Neoral, Sandimmune, Gengraf) within the past 24 hours. Using tacrolimus may increase your risk of developing serious infections or certain types of cancer, such as lymphoma or skin cancer.

What are the long term side effects of tacrolimus?

Commonly reported side effects of tacrolimus include: opportunistic infection, diabetes mellitus, infection, headache, hyperglycemia, hyperkalemia, increased blood urea nitrogen, increased serum creatinine, mental status changes, nephrotoxicity, sensation disorder, and tremor.

Can you switch brands of tacrolimus?

Changing oral tacrolimus products

This updated recommendation does not preclude patients changing to a different tacrolimus brand if the prescriber considers this to be of benefit to the patient.

When did Prograf go generic?

On August 25, 2017, the FDA approved an AP-rated generic version of Astellas' Prograf (tacrolimus) 5 mg/mL injection. Prograf is approved for the prophylaxis of organ rejection in patients receiving allogeneic kidney, heart, or liver transplants.

Does tacrolimus affect the heart?

In 100 people receiving Tacrolimus, from 4 to 20 may have: Damage to organs (heart, lungs, brain, others) which may cause changes in thinking, confusion, memory loss or shortness of breath.

What happens if you stop taking tacrolimus?

While you are being treated with tacrolimus, and after you stop treatment with it, do not have any immunizations (vaccines) without your doctor's approval. Tacrolimus may lower your body's resistance and the vaccine may not work as well or you might get the infection the vaccine is meant to prevent.

How can I increase my tacrolimus naturally?

Tacrolimus should be taken on a consistent schedule before or after you eat at the same times each day. Grapefruit and grapefruit juice may increase the amount of tacrolimus in your body.

Does tacrolimus affect kidney function?

Tacrolimus may decrease kidney function, usually if blood levels of tacrolimus are too high. This is why blood work is checked frequently to adjust the dosage of tacrolimus.

Can tacrolimus cause liver damage?

The liver injury due to tacrolimus is usually mild and self-limiting and responses rapidly to dose adjustment or drug discontinuation. Other calcineurin inhibitors and immunosuppressants are generally tolerated, but rare instances of cross sensitivity to hepatic injury by cyclosporine and tacrolimus have been reported.

What is a normal tacrolimus level for a kidney transplant patient?

Generally, the tacrolimus trough level maintained between 5.35 and 7.15 ng/mL may be optimal during the first month after living relative kidney transplantation among the Chinese.

What are the best anti rejection drugs kidney transplant?

The most commonly used immunosuppressants include:
  • Prednisone.
  • Tacrolimus (Prograf)
  • Cyclosporine (Neoral)
  • Mycophenolate Mofetil (CellCept)
  • Imuran (Azathioprine)
  • Rapamune (Rapamycin, Sirolimus)

What medications should be avoided after kidney transplant?

Medicines to avoid when you're taking immunosuppressants
  • aluminum or magnesium-based antacids (such as Maalox)
  • some antibiotics (for example, Erythromycin)
  • some medicines to prevent seizures (called anti-seizure medicines)
  • cholestyramine (Questran)
  • herbal medicines and remedies ( St. John's wort, Echinacea, for example)

Does tacrolimus make your hair fall out?

While those medications are essential in allowing the body to accept the transplant, like virtually all medicine, they can have side effects. Tacrolimus can cause hair loss. Ironically, cyclosporine can cause unwanted hair growth in some people but doesn't affect those who are already totally bald.

Where does tacrolimus come from?

It is produced by a soil bacterium, Streptomyces tsukubensis. The name tacrolimus is derived from "Tsukuba macrolide immunosuppressant". Tacrolimus was first approved by the US Food and Drug Administration (FDA) in 1994, for use in liver transplantation; the indications were extended to include kidney transplants.

Where is Prograf manufactured?

The API of the drug is currently being manufactured, formulated and packed in the Toyama Technology Centre for Japan and overseas markets. The company claimed that its Prograf has supported the global medical transplantation as a first-line immunosuppressant for organ transplantation, and has recorded JPY195.