What is stronger than Ozempic for weight loss?


Editorial team Published on

Zepbound and Mounjaro (tirzepatide) are stronger than Ozempic for weight loss because they activate two hormone receptors instead of one.

Stronger FDA-Approved Medications

  • Zepbound / Mounjaro (Tirzepatide): This dual-action drug targets both GLP-1 and GIP receptors. It helps patients lose an average of 20% to 25% of their body weight in clinical trials. Ozempic typically leads to a 10% to 15% loss.
  • Wegovy (High-Dose Semaglutide): This uses the exact same active ingredient as Ozempic. However, it comes in a higher maximum dose (2.4 mg) and is specifically approved for long-term weight management.

Emerging Therapies in Clinical Trials

  • Retatrutide: This is a new "triple-agonist" drug that targets three receptors (GLP-1, GIP, and glucagon). Early trial data shows participants losing up to 24% to 30% of their body weight. It is still going through clinical testing.