What painkillers can you not take together?

Asked by: Richard Quitzon  |  Last update: October 12, 2025
Score: 4.9/5 (1 votes)

It's safe to take ibuprofen with paracetamol or codeine. But do not take ibuprofen with similar painkillers like aspirin or naproxen without talking to a pharmacist or doctor. Ibuprofen, aspirin and naproxen belong to the same group of medicines called non-steroidal anti-inflammatory drugs (NSAIDs).

What pain medications should not be taken together?

The bottom line for weekend warriors is that you cannot combine ibuprofen and naproxen unless it is time for another dose of either medication. If you need additional pain relief, you can combine aspirin, naproxen, or ibuprofen with acetaminophen.

Can you take 2 different painkillers at the same time?

It may be possible to take some of the drugs at a higher dose when prescribed by a doctor. Different NSAIDs shouldn't be combined with each other. But an NSAID can be combined with acetaminophen (paracetamol) if one medication alone isn't effective enough.

What medications should never be taken together?

What Are the 7 More Dangerous Medicines to Mix?
  • Alcohol and opioids.
  • Opioids and benzodiazepines.
  • Warfarin and acetaminophen.
  • Warfarin and ibuprofen.
  • PDE-5 inhibitors and nitrates.
  • Statins and amiodarone.
  • ACE inhibitors and potassium supplements.

Can I take oxycodone with Tylenol and ibuprofen?

It's safe to take oxycodone with paracetamol, ibuprofen or aspirin (do not give aspirin to children under 16 years of age). Do not take oxycodone with painkillers that contain codeine. You'll be more likely to get side effects.

What over-the-counter painkiller is the best at killing pain?

25 related questions found

What not to mix with oxycodone?

don't take oxycodone with other opioids, alcohol or other sedating drugs such as Gravol and benzodiazepines (e.g., Xanax, Ativan, Valium) don't take oxycodone by yourself, with no one to help you if you overdose. don't take oxycodone soon after you've gone through withdrawal from opioids.

What is stronger than oxycodone?

Dilaudid is significantly stronger—about 4-5 times more potent than Oxycodone—making it a go-to option for treating severe, chronic pain or for patients who have developed a tolerance to other opioids. It is commonly administered in hospitals for acute pain and is available in injectable and oral forms.

What two pills should you never mix?

Common Risks of Mixing Prescription with OTC Drugs
  • Warfarin and Ibuprofen. ...
  • Acetaminophen and Multi-Symptom Cold Medications. ...
  • Antidepressants and NSAIDs. ...
  • Grapefruit Juice and Fexofenadine (Allegra) ...
  • Alcohol and Acetaminophen (Tylenol) ...
  • Milk and Ciprofloxacin or Levofloxacin. ...
  • Chocolate and Antidepressants. ...
  • Licorice and Digoxin.

What drugs have major interactions?

Below are a few notable examples of drug-condition interactions.
  • Propranolol and asthma. ...
  • Diphenhydramine and glaucoma. ...
  • Pseudoephedrine and high blood pressure. ...
  • Furosemide and severe kidney disease. ...
  • Acetaminophen and liver disease. ...
  • Fluconazole and simvastatin. ...
  • Ondansetron and dofetilide. ...
  • Digoxin and amiodarone.

What are the top 3 pain relievers?

The most common types of OTC pain medicines are acetaminophen, aspirin, and nonsteroidal anti-inflammatory drugs (NSAIDs).

What not to say to your pain management doctor?

Navigating Pain Management Conversations: Phrases to Avoid
  • “I Just Need a Stronger Prescription” ...
  • “My Pain is a 10 Out of 10 All the Time” ...
  • “I Don't Believe in Non-Drug Therapies” ...
  • “It's Just Minor Discomfort” ...
  • “That's Not Going to Work for Me” ...
  • “I Saw This Treatment Online…” ...
  • Describing the Type of Pain.

Which is stronger, percocet or oxycodone?

Neither medication is more effective than the other, although the acetaminophen in Percocet affects different receptors than oxycodone in the pain pathway. The choice of medication depends on the type of pain and the health of the individual.

What drugs cannot be taken with opioids?

Drugs and substances that may interact with prescribed opioid medications include:
  • Alcohol.
  • Anti-seizure medications, such as carbamazepine.
  • Benzodiazepines and sedatives.
  • Certain antibiotics, including clarithromycin.
  • Certain antidepressants.
  • Certain antifungals, including itraconazole, ketoconazole and voriconazole.

What is the strongest painkiller?

Strong opioids - these include tramadol, buprenorphine, methadone, diamorphine, fentanyl, hydromorphone, morphine, oxycodone, and pethidine.

What should be the gap between painkillers?

Paracetamol. You can only take 2 paracetamol (500mg) every 4 to 6 hours, and no more than 8 in 24 hours. You shouldn't take any more than this amount. Always follow the instructions on the packet.

What is hydrocodone used for?

Hydrocodone is an antitussive (cough suppressant) and narcotic analgesic agent for the treatment of moderate to moderately severe pain. Studies indicate that hydrocodone is as effective, or more effective, than codeine for cough suppression and nearly equipotent to morphine for pain relief.

What is the biggest killer of sudden cardiac death?

Coronary heart disease (CHD) remains the most common cardiac cause of sudden unexplained death in people of all ages. Coronary heart disease is caused by the build-up of plaque in the coronary arteries. These arteries supply blood to the heart.

What are the worst blood pressure drugs to take?

4 worst blood pressure drugs
  • Beta-Blockers: Limited Efficacy and High Adverse Effects. Efficacy Concerns. ...
  • High-Dose Thiazides: Increased Adverse Effects Without Mortality Benefit. Efficacy Concerns. ...
  • Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Blood Pressure Elevation. ...
  • Antidepressants: Variable Impact on Blood Pressure.

What pills don't go together?

Pills with antihistamines.
  • An NSAID pain reliever with a blood pressure drug.
  • A thyroid drug called levothyroxine with an acid-blocking proton pump inhibitor drug called omeprazole.
  • An SSRI antidepressant with another medicine that affects serotonin (such as dextromethorphan, linezolid, tramadol, and trazodone)

What does gabapentin do?

Gabapentin is used to treat epilepsy. It's also taken for nerve pain, which can be caused by different conditions, including diabetes and shingles. Nerve pain can also happen after an injury. In epilepsy, it's thought that gabapentin stops seizures by reducing the abnormal electrical activity in the brain.

What is the fastest way for a drug to reach one's brain?

The fastest way to get a drug to the brain is by smoking it. When a drug like tobacco smoke is taken into the lungs, nicotine (the addictive chemical in tobacco) seeps into lung blood where it can quickly travel to the brain. This fast delivery is one reason smoking cigarettes is so addicting.

Which is stronger, Norco or Percocet?

One study by James P. Zacny and Sandra Gutierrez from the University of Chicago found that Percocet is 1.5 times stronger than Norco. However, both Percocet and Norco are very potent pain relievers, with several other studies finding little to no difference between them in terms of potency.

What is the strongest drug for nerve pain?

Tramadol. Tramadol is a powerful painkiller related to morphine that can be used to treat neuropathic pain that does not respond to other treatments a GP can prescribe. Like all opioids, tramadol can be addictive if it's taken for a long time. It'll usually only be prescribed for a short time.

Is oxycodone used for end of life?

I thought oxycodone was only used at the end of life? No. Oxycodone is used for different sorts of moderate and severe pain. If you have cancer, treatment with oxycodone may be needed to allow you to live as comfortably as possible.