What works better than Ozempic for weight loss?

Asked by: Helga Schimmel  |  Last update: September 24, 2025
Score: 4.1/5 (6 votes)

In a recent study published in JAMA Internal Medicine, researchers compared Ozempic and Mounjaro in real-world conditions and found that people who took Mounjaro lost significantly more weight than those who took Ozempic.

What is the new weight loss drug better than Ozempic?

GLP-1 helps to regulate appetite and reduce blood sugar levels and so taking these medications enhances these effects in the body. “Mounjaro is considered more effective than Ozempic and Wegovy because it acts on GLP-1 receptors as well as the receptors of another hormone called GIP.

What is the best alternative to Ozempic for weight loss?

If you're having trouble accessing Ozempic, your healthcare team may recommend an alternative that works in a similar way. For Type 2 diabetes, this may include Rybelsus, Trulicity, or Mounjaro. If you're taking Ozempic off-label for weight loss, Wegovy, Zepbound, and Saxenda are three FDA-approved options.

What is the strongest weight loss injection?

What is the best weight loss injection? The new weight loss drug Zepbound (tirzepatide) has shown the best results in clinical trials. It has an additional mechanism of action on GIP receptors in addition to GLP-1 receptors and may, therefore, have greater weight loss benefits.

Do you lose more weight on Mounjaro or Ozempic?

Mounjaro leads to significantly more weight loss than Ozempic, study suggests. He lost 40 pounds on Mounjaro. Can he maintain it without the drug? People taking tirzepatide injections lost more weight and were more likely to reach specific weight loss targets than those taking semaglutide, according to a new study.

Mounjaro is more effective than Ozempic for weight loss, study finds

30 related questions found

Can you lose 20 pounds in a month on Mounjaro?

According to data from randomised controlled trials, Mounjaro supports weight loss of around 4% of body weight after one month. After two months, it's around 6% of body weight.

How did Kelly Clarkson lose weight?

Kelly Clarkson's weight loss was motivated by health concerns, including autoimmune and thyroid conditions. She combined diet changes, such as adopting a lectin-free diet, with regular exercise like walking. Clarkson's journey included using weight loss medication, although she emphasized a holistic approach.

What is the $1000 weight loss drug?

Private insurance companies say U.S. patients aren't paying the true cost of expensive medications such as Wegovy and Zepbound, which can easily cost upwards of $1,000.

How to lose 50 pounds in 3 months?

Steps
  1. Eat fewer calories than your body needs to lose weight. ...
  2. Eat smaller meals more frequently. ...
  3. Include more protein in your diet. ...
  4. Increase your fiber intake. ...
  5. Drink plenty of water to stay hydrated and boost your metabolism. ...
  6. Cut out alcohol and sugary drinks. ...
  7. Add more whole foods to your diet and avoid processed foods.

How to lose 20 pounds in a month?

Losing 20 pounds in 1 month may be easier than 2 weeks, but it's still unrealistic for most people. Once again, it comes down to your TDEE and simple math. To lose 20 pounds in 1 month, you'd need to create an average deficit of 2,500 calories per day for 4 weeks. This might be possible for larger men.

What is the new drug to replace Ozempic?

Wegovy (semaglutide) Wegovy is the same medication as Ozempic and was FDA-approved for chronic weight management in 2021. It's even sometimes referred to as “the new Ozempic.” For dosing, you'll start off on a 0.25mg injection per week, then your doctor may increase every month until you reach 1.7mg or 2.4mg per week.

How much does Mounjaro cost without insurance?

Mounjaro (tirzepatide) is a prescription medication that's FDA approved to treat Type 2 diabetes. Without insurance, the average monthly cost of Mounjaro is between $1,000 to $1,200, depending on the pharmacy.

What is better weight loss with Ozempic or Wegovy?

Ozempic for weight loss: which is better? In a clinical trial that compared weekly use of semaglutide 1 mg and 2.4 mg, semaglutide 2.4 mg (the maximum dose of Wegovy) caused more weight loss than semaglutide 1 mg (the typical maintenance dose of Ozempic).

What is the Ozempic face?

“Ozempic face” is a nonmedical term that refers to the gaunt appearance in the face that can happen when someone loses weight quickly, specifically while taking a GLP-1 drug such as Ozempic. The rapid loss of fat from the face is the cause of the hollowed cheeks and looser skin.

Can you really get Wegovy for $25?

Yes, you can really get Wegovy for $25 if you meet certain criteria. Offered by Novo Nordisk, the Wegovy Savings Card awards qualified individuals the opportunity to get the medication for $25 per month (i.e. 28-day supply).

How long do you have to walk each day to lose 50 pounds?

Carlo, a home assistant expert and social media influencer, lost a whopping 50 pounds in 8 months with the help of daily walks. In a viral video he explains exactly how he did it. “I lost around 50 pounds basically walking an hour every day.

How to lose 5 pounds in a week?

Losing 5 pounds a week comes to reducing your food intake by 3500 calories over seven days. The value that represents the decrease in calorie intake is known as the calorie deficit. If you want to lose 5 pounds in a week, you will need to reduce your food intake by 17,500 calories, which is a huge calorie deficit.

Can I lose 30 lbs in 3 months?

Rapid weight loss may lead to weight regain through metabolic changes, muscle loss, hormonal changes, and possibly frustration with the restrictions associated with dieting. With that in mind, for many people, 3 months is a realistic timeframe for losing 30 pounds. That amounts to losing a little over 2 pounds a week.

Is Mounjaro better than Ozempic?

Several studies have shown that Mounjaro is more effective than Ozempic for blood sugar control and weight loss. In the SURPASS-2 trial, tirzepatide outperformed semaglutide in reducing A1C levels.

What is the most powerful weight loss drug?

Some of the strongest weight loss pills available today include:
  • Naltrexone/bupropion (brand name Contrave)
  • Phentermine/topiramate (brand name Qsymia)
  • Orlistat (brand names Xenical, Alli)
  • Phentermine (brand names Adipex-P, Lomaira)

How did Melissa McCarthy lose weight?

Melissa told People magazine that after she landed her role on Gilmore Girls, she attempted a doctor-supervised all-liquid diet, which led her to lose 70 pounds in four months.

How did Adele lose weight?

Adele's routine involved daily workouts, including weight training and cardio. She worked with a trainer to create a balanced plan that fit her lifestyle. This consistent exercise helped her build strength and boost her fitness level.

How did Rebel Wilson lose weight?

She has claimed in the past to have achieved her weight loss purely through workouts with a trainer and by adding protein to, and cutting sugar from, her diet. Despite some horror stories about the side-effects of Ozempic, including severe nausea, Rebel added: "I actually liked it.