Who Cannot take Excedrin migraine?

Asked by: Braxton Hackett  |  Last update: September 26, 2025
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Before using this medication, tell your doctor or pharmacist your medical history, especially of: asthma (including a history of worsening breathing with runny/stuffy nose after taking aspirin or other NSAIDs such as ibuprofen, naproxen), certain blood disorders (such as anemia), bleeding or blood clotting problems ( ...

Who should not use Excedrin?

You should not use Excedrin if you are allergic to acetaminophen (Tylenol), aspirin, caffeine, or any NSAIDs (Advil, Motrin, Aleve, Orudis, Indocin, Lodine, Voltaren, Toradol, Mobic, Relafen, Feldene, and others). Aspirin may cause stomach or intestinal bleeding, which can be fatal.

Can people with high blood pressure take Excedrin Migraine?

CNS stimulants (applies to Excedrin Migraine) hypertension

Caution should be used when administering to patients with preexisting high blood pressure (even mild hypertension) and other cardiovascular conditions. All patients under treatment should be regularly monitored for potential tachycardia and hypertension.

What is the difference between regular Excedrin and Excedrin Migraine?

Excedrin Migraine is meant to relieve pain associated with headaches and migraines. Excedrin Extra Strength is more versatile and is generally used to relieve minor aches and pains related to various causes. For this reason, their labeling and dosing recommendations are different.

What is a good alternative to Excedrin for migraines?

  • Sumatriptan.
  • Imitrex.
  • Ubrelvy.
  • Nurtec ODT.
  • Rizatriptan.
  • Memantine.

Can't find your Excedrin Migraine pills at the pharmacy? Here's why

40 related questions found

What's better for Migraine ibuprofen or Excedrin?

Advil Migraine and Excedrin Migraine are both effective for treating migraines. Research shows that the ingredients in Excedrin Migraine are more effective at reducing migraine pain than ibuprofen. The ingredients in Excedrin Migraine also kick in about 20 minutes faster.

Why can you only take 2 Excedrin Migraine per day?

Excedrin Migraine contains 250 mg of acetaminophen, 250 mg of aspirin (an NSAID), and 65 mg of caffeine per caplet or geltab. Taking more than 2 caplets in 24 hours may cause an overdose of acetaminophen, especially if you are using other medicines that contain acetaminophen.

What does Excedrin do to your body?

This product is a combination of aspirin, acetaminophen, and caffeine. It is used for the temporary relief of pain from conditions such as muscle aches, toothaches, menstrual cramps, or headaches (including migraine). Aspirin and acetaminophen relieve pain by keeping your body from making certain natural substances.

What is the best medicine for migraines with high blood pressure?

Options include: Blood pressure-lowering medications. These include beta blockers such as propranolol (Inderal, InnoPran), Hemangeol) and metoprolol (Lopressor). Calcium channel blockers such as verapamil (Verelan, Calan) can be helpful in preventing migraines with aura.

What medications does Excedrin interact with?

Some products that may interact with this drug are: acetazolamide, cimetidine, corticosteroids (such as prednisone), dichlorphenamide, ketoconazole, levoketoconazole, methotrexate, mifepristone, certain medications for gout (such as probenecid, sulfinpyrazone), anti-seizure drugs (such as phenytoin, valproic acid), ...

What are the worst blood pressure drugs to take?

4 worst blood pressure drugs
  • Beta-Blockers: Limited Efficacy and High Adverse Effects. Efficacy Concerns. ...
  • High-Dose Thiazides: Increased Adverse Effects Without Mortality Benefit. Efficacy Concerns. ...
  • Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Blood Pressure Elevation. ...
  • Antidepressants: Variable Impact on Blood Pressure.

Can you take Excedrin while on blood pressure medicine?

The combination may cause your blood pressure to increase. You may need a dose adjustment or your blood pressure checked more often.

Can Excedrin cause anxiety?

Common Excedrin Migraine side effects may include: upset stomach, heartburn; depressed mood, feeling anxious or restless; or. sleep problems (insomnia).

How long does it take for Excedrin to wear off?

How long does Excedrin Migraine last? In three placebo-controlled studies, an acetaminophen, aspirin, and caffeine combination (equivalent to Excedrin Migraine) was shown to last up to 6 hours when taken to relieve migraine headache pain.

What is the #1 migraine medication?

Drugs known as triptans came out on top, based on real-world data from some 278,000 migraine sufferers. If you suffer from the throbbing, intense pain set off by migraine headaches, you may well wonder which medicines are most likely to offer relief.

Is there a difference between Excedrin and Excedrin Migraine?

The only difference between Excedrin Extra Strength and Excedrin Migraine, is the labeling and dosage recommendation. It's a legal issue. In order for Excedrin to put “Migraine Relief” on the bottle, it had to resubmit to the FDA and get the “new” (but really the same) product re-approved.

Why won't my headache go away after taking medicine?

If you have migraine or tension-type headaches and you take pain medicine more than a couple of times a week, you could have medication-overuse headache. This is a common cause of headaches that won't go away. Or you may have developed a new trigger.

What is the miracle drug for migraines?

Aimovig is a brand-name prescription drug that's FDA-approved to prevent migraine headaches in adults. Aimovig can be used to prevent both episodic and chronic migraine headaches.

What are the 5 C's of migraines?

In other words there is more to diet and migraine than simply excluding the 5 Cs (cheese, chocolate, coffee, coke, and citrus fruits). They performed double blind challenges in a selection of their cases; these were confirmatory of the results of open challenge in the majority of cases.

What is the strongest migraine pain relief?

Triptans, a drug usually offered as an alternative to painkillers, have been found to be the most effective medicine for adults who experience acute migraines.

Why did they stop making Excedrin Migraine?

The drug's maker found problems in how ingredients were measured in Excedrin Extra Strength and Excedrin Migraine. Pharmaceutical giant GlaxoSmithKline has temporarily stopped production of Excedrin, its popular over-the-counter migraine medication.

What is the best over-the-counter medicine for migraines?

Acetaminophen (Tylenol), non-steroidal anti-inflammatory drugs (NSAIDs) like aspirin, and caffeine are common ingredients found in OTC migraine products. Some research suggests that the combination of acetaminophen, aspirin, and caffeine (Excedrin Migraine) may work better and faster than other options.

When should you not take Excedrin?

Excedrin Extra Strength Interactions

May potentiate anticoagulants, hypoglycemics, methotrexate. May antagonize uricosurics. Increased risk of liver toxicity and/or GI bleed with ≥3 alcoholic drinks/day or concomitant other drugs containing acetaminophen, NSAIDs. Caution with diuretics, corticosteroids.