Why is Mounjaro better than Ozempic?

Asked by: Roger Hintz  |  Last update: November 9, 2025
Score: 4.8/5 (4 votes)

While they are approved for diabetes, both Mounjaro and Ozempic also make people lose weight by helping you to feel full longer. Ozempic acts like a hormone your body makes. Mounjaro works similarly, but it acts like two hormones instead of one. Compared to Ozempic, Mounjaro might work even better for weight loss.

Does Mounjaro work better than Ozempic?

Whether Mounjaro or Ozempic is better depends on your needs and treatment goals. While Mounjaro is more effective for lowering A1C (your average blood sugar levels over three months) and weight loss, Ozempic is FDA-approved to prevent heart complications in people with type 2 diabetes and cardiovascular disease.

What happens when you switch from Ozempic to Mounjaro?

Key takeaways

Mounjaro may result in more weight loss and tighter diabetes management than Ozempic, but Mounjaro may also cause more gastrointestinal side effects. A healthcare provider can help determine whether switching medications makes sense for your situation.

What is the average weight loss on Mounjaro?

The trial concludes that individuals can achieve an average weight loss ranging from 15% to 22% of their initial body weight after 72 weeks when combined with a healthy diet and exercise.

Can you lose 20 pounds in a month on Mounjaro?

According to data from randomised controlled trials, Mounjaro supports weight loss of around 4% of body weight after one month. After two months, it's around 6% of body weight.

Mounjaro may be 3 times more effective than Ozempic, study finds

29 related questions found

How did Kelly Clarkson lose weight?

Kelly Clarkson's weight loss was motivated by health concerns, including autoimmune and thyroid conditions. She combined diet changes, such as adopting a lectin-free diet, with regular exercise like walking. Clarkson's journey included using weight loss medication, although she emphasized a holistic approach.

How quickly do you lose weight on Mounjaro?

After 8 weeks, if you have tolerated your current Mounjaro dose well, it may be increased to 7.5mg per week. During these weeks, you are likely to start seeing some of the effects of weight loss. After 12 weeks of treatment, you might expect to lose up to 8% of your body weight.

What medicines can you not take with Mounjaro?

Key Mounjaro (tirzepatide) drug interactions include insulin, sulfonylureas, and glinides. Taking them together can cause your blood glucose (sugar) to drop too low. Mounjaro can also make birth control pills less effective and may affect how your body absorbs other oral medications.

Can I go straight from Ozempic to Mounjaro?

Yes, you can switch between Ozempic and Mounjaro under the supervision of a healthcare professional.

Why am I not losing weight on Mounjaro?

You can stop losing weight on Mounjaro for many reasons, but diet, dosage and lifestyle issues are the most common. It also takes time for Mounjaro to work and for you to reach the highest maintenance dose.

How much does Mounjaro cost without insurance?

Mounjaro (tirzepatide) is a prescription medication that's FDA approved to treat Type 2 diabetes. Without insurance, the average monthly cost of Mounjaro is between $1,000 to $1,200, depending on the pharmacy.

Why am I so sick on Mounjaro?

Since it significantly slows down your gut, Mounjaro can come with some uncomfortable GI side effects. For most people, the symptoms are mild to moderate and go away after your body gets used to the medicine. People usually have these symptoms when they first start Mounjaro and each time they raise their dose.

Which side effects are worse, Ozempic or Mounjaro?

They have similar side effects, like nausea, vomiting, and constipation, but Mounjaro tends to cause more serious stomach problems; Mounjaro targets two receptors linked to weight loss, while Ozempic focuses on just one; To get the best results from these meds, it's important to pair them with healthy eating.

Do you gain weight back after stopping Mounjaro?

Weight gain is common when you stop GLP-1 weight loss medications like Mounjaro, and studies show people can put up to 14% of their weight back on. When you stop Mounjaro, its beneficial effects stop too. Some people notice an increase in their appetite and may revert back to their previous diet.

Can I have a glass of wine on Mounjaro?

Mounjaro and alcohol

Mounjaro isn't known to interact with alcohol. However, your doctor may advise you to limit the amount of alcohol you consume while using Mounjaro. This is because alcohol can affect blood sugar levels.

Who cannot use Mounjaro?

MOUNJARO is contraindicated in patients with a personal or family history of MTC or in patients with MEN 2. Counsel patients regarding the potential risk for MTC with the use of MOUNJARO and inform them of symptoms of thyroid tumors (e.g., a mass in the neck, dysphagia, dyspnea, persistent hoarseness).

Can I lose 60 pounds on Mounjaro?

15 news release. About 580 people lost at least 5% of their weight after the 12 weeks, and among that cohort, they were split between taking Mounjaro or a placebo. After 84 weeks, participants who took Mounjaro lost, on average, 26.6% of their weight — equal to 64.4 pounds each.

Can you lose belly fat with Mounjaro?

With enhanced lipid metabolism, Mounjaro aids in the breakdown of stored fats, particularly those in adipose tissue. This process is essential for reducing stubborn fat in hard-to-lose areas, such as the abdomen and thighs.

What happens if you eat too little on Mounjaro?

If you're consistently losing weight quicker than 2 lbs per week, you're probably eating too little on Mounjaro. Losing weight too quickly can lead to increased medication side effects, loss of muscle mass and other lean tissues, and an increased risk of micronutrient deficiencies.

How did Adele lose weight?

Adele's routine involved daily workouts, including weight training and cardio. She worked with a trainer to create a balanced plan that fit her lifestyle. This consistent exercise helped her build strength and boost her fitness level.

How did Melissa McCarthy lose weight?

Melissa told People magazine that after she landed her role on Gilmore Girls, she attempted a doctor-supervised all-liquid diet, which led her to lose 70 pounds in four months.

What is the strongest weight loss prescription pill?

Some of the strongest weight loss pills available today include: Naltrexone/bupropion (brand name Contrave) Phentermine/topiramate (brand name Qsymia) Orlistat (brand names Xenical, Alli)