What's the most painful illness to live with?

Asked by: Prof. Cleveland McGlynn  |  Last update: June 13, 2025
Score: 4.4/5 (49 votes)

CRPS is not a short-term pain that will heal in time. The most excruciating part is that the pain is long-term, and likely to be for life. In fact, CRPS is known as the world's most painful incurable condition.

What is the most painful condition to live with?

20 most painful conditions
  • Sciatica. ...
  • Kidney stones. ...
  • Trigeminal neuralgia. ...
  • Endometriosis. ...
  • Gout. ...
  • Acute pancreatitis. ...
  • Stomach or peptic ulcer. Peptic ulcers are open sores that form in the lining inside the stomach. ...
  • Fibromyalgia. Fibromyalgia is a condition that causes pain all over the body (widespread musculoskeletal pain).

What is the most painful disorder to live with?

Not only is BPD one of the most painful mental illnesses, but it's also intensified by stigma and being misunderstood by others.

Which disease is most painful?

20 painful health conditions
  • Appendicitis.
  • Trigeminal neuralgia.
  • Acute pancreatitis.
  • Gout.
  • Endometriosis.
  • Stomach ulcer.
  • Fibromyalgia.
  • Pain after surgery.

What is the #1 most painful thing in the world?

1. Kidney stones. If you've ever suffered from a kidney stone, you know why it ranks high on the pain scale.

Living With The World's Most Painful Disease | MSNBC

31 related questions found

What is the hardest chronic illness to live with?

Here's a list of debilitating diseases that significantly change the lives of millions of people:
  1. Alzheimer's and Dementia.
  2. Amyotrophic Lateral Sclerosis (ALS) – Lou Gherig's Disease. ...
  3. Parkinson's Disease. ...
  4. Multiple Sclerosis (MS) ...
  5. Scleroderma. ...
  6. Cystic Fibrosis. ...
  7. Chronic Obstructive Pulminary Disease (COPD) ...
  8. Cerebral Palsy. ...

What rare disease has no pain?

Congenital insensitivity to pain and anhydrosis (CIPA) is a very rare and extremely dangerous condition. People with CIPA cannot feel pain [1].

What disease is hard to treat?

dementia, including Alzheimer's disease. advanced lung, heart, kidney and liver disease. stroke and other neurological diseases, including motor neurone disease and multiple sclerosis. Huntington's disease.

How painful are shingles on a scale of 1 to 10?

“Shingles is extremely painful," Wigand-Bolling said. “On a scale from one to 10, most patients will say the pain ranges from six to 10.” Between 1 and 5 days after the first symptoms occur, a rash will develop in the affected area.

What's the worst disorder you can have?

What Is the Hardest Mental Illness to Live With?
  • Schizophrenia.
  • Severe Bipolar Disorder.
  • Borderline Personality Disorder (BPD)
  • Major Depression and Treatment-Resistant Depression.
  • Obsessive-Compulsive Disorder (OCD)
  • Eating Disorders.
  • Post-Traumatic Stress Disorder (PTSD)
  • So, What is the hardest mental illness to live with?

What is the BPD stare?

One of the lesser-known symptoms of BPD is the "stare," a piercing and intense gaze that can be unsettling for others. While the stare is not a diagnostic criterion for BPD, it is often reported by people with BPD and can be a sign of emotional dysregulation.

What is the most painful injury?

In the realm of most painful injuries, compound fractures deserve a mention. These fractures occur when a broken bone pierces through the skin. Not exclusive to sports. But they can happen during high-impact activities like football or motocross.

What is the disease where you hurt all the time?

Fibromyalgia is a disorder characterized by widespread musculoskeletal pain accompanied by fatigue, sleep, memory and mood issues. Researchers believe that fibromyalgia amplifies painful sensations by affecting the way your brain and spinal cord process painful and nonpainful signals.

What are the most painful mental illnesses to live with?

The Most Painful Mental Illness
  • Depression.
  • Anxiety.
  • Bipolar Disorder.
  • Borderline Personality Disorder (BPD)
  • Post-Traumatic Stress Disorder (PTSD)

Which illness has no cure?

These include:
  • Alzheimer's disease.
  • Multiple sclerosis.
  • Asthma.
  • Crohn's disease.
  • Creutzfeldt–Jakob disease.
  • Diabetes.

What is the most feared disease?

The Most Feared Pathogens: 9 Diseases that Could Cause a Major epidemic
  • Lassa fever. ...
  • Crimean-Congo Haemorrhagic Fever (CCHF) ...
  • Rift Valley Fever virus. ...
  • MERS. ...
  • SARS. ...
  • 8 & 9. ...
  • Chikungunya and Zika. ...
  • Disease X.

What is the hardest disorder to cure?

Borderline personality disorder historically has been viewed as challenging to treat.

What is the most painful incurable disease?

In fact, CRPS is known as the world's most painful incurable condition. In the United States, it is referred to as the “suicide disease” as it can lead sufferers to resort to suicide as the only means to escape the huge pain that they bear.

What is the rarest disease on Earth?

RPI Deficiency

This is considered to be the rarest disease in the world. Ribose-5-Phosphate Isomerase (RPI), is a crucial enzyme in a metabolic process in the human body.

What is palmers syndrome?

Introduction: Palmer's disease (or Palmer's syndrome) is poorly understood and is due to traumatic rupture of the internal collateral ligament of the knee at the femoral insertion.

What's the worst pain a human can feel?

The full list, in no particular order, is as follows:
  • Appendicitis.
  • Trigeminal neuralgia.
  • Acute pancreatitis.
  • Gout.
  • Endometriosis.
  • Stomach ulcer.
  • Fibromyalgia.
  • Pain after surgery.

What is the deadliest chronic disease?

Heart disease. The NCHS figures show that 702,880 people died from heart disease in 2022. There are many different types of heart disease, and together, they are the leading cause of death in the U.S. Coronary artery disease (CAD) is the most common form of heart disease.

What is the most crippling mental illness?

Despite 50 years of pharmacological and psychosocial intervention, schizophrenia remains one of the top causes of disability in the world [2].